Hotel 21C
Lifestyle by Ennismore At the corner of curiosity
Hotel 21C

At the corner of curiosity

Contemporary Art Museum

21c Museum Hotels pushes the boundaries of both the museum and hotel worlds to create a new kind of travel experience. Founded as a single property by contemporary art collectors and preservationists Laura Lee Brown and Steve Wilson, whose mission was to share innovative contemporary art with the public. With locations ranging from 19th century warehouses to banks, 21c Museum Hotels create a union of genuine hospitality, thoughtful design, and culinary creativity — all anchored by a contemporary art museum.

Take me to 21c

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Our hotels selection

  • 21c Museum Hotel Louisville

    Nestled in downtown Louisville on historic West Main Street, along Museum Row, 21c Museum Hotel Louisville is a multi-venue contemporary art museum, an award-winning 91-room boutique hotel, and home to acclaimed Proof on Main restaurant. Stay with us andthe iconic Red Penguin.

  • 21c Museum Hotel Chicago

    21c Museum Hotel Chicago is ideally situated in downtown just steps from the iconic Michigan Avenue. 21c welcomes both visitors and locals to enjoy the curated exhibitions cultural programming and culinary offerings. In addition to its proximity to Magnificent Mile 21c is also within walking distance of cultural attractions including the Museum of Contemporary Art the John Hancock Center Millennium Park the Historic Water Tower and Navy Pier. 21c is an art filled escape from it all.

  • 21c Museum Hotel Kansas City

    Feed, nourish, and refresh your soul at 21c Museum Hotel Kansas City. #1 hotel in the Midwest and #15 in the world by Condé Nast Traveler 2021. Let contemporary art surround you in this museum, boutique hotel, and chef-driven restaurant, nestled between the Power & Light district and River Market in downtown Kansas City.

  • 21c Museum Hotel Cincinnati

    Situated in the heart of The Queen City, adjacent to the Contemporary Art Center and across the street from the Aronoff Center for the Arts, 21c Museum Hotel Cincinnati is a multi-venue contemporary art museum, an award-winning 156-room boutique hotel and home of Metropole restaurant. Stay with us and the iconic Yellow Penguin.

  • 21c Museum Hotel Durham

    Standing tall and proud in the center of downtown Durham, 21c Museum Hotel Durham is a multi venue contemporary art museum offering more than 10,500 square feet of art filled exhibition and event space, a full service boutique hotel with luxurious guest rooms, and home to Counting House restaurant.

  • 21c Museum Hotel St Louis

    Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.


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*Prices start from, based on a one night stay in a standard double room for two guests. Supplementary services, breakfast and tourist/city tax are not included. Price observed on within the past 24 hours, for a one night stay within the next eight days, starting tomorrow. Price subject to the hotel conditions, period and availability. Depending on the country, these prices may not include taxes, may include VAT only or may include all taxes (VAT and tourist/city tax). When prices do not include all taxes, the relevant taxes (VAT and tourist/city tax) will be stated in the forthcoming stages of the reservation process. The price is only guaranteed at the time of reservation.
**Some hotels in this brand are not participants in the ALL loyalty programme. See the list of non-participating hotels